Provera (medroxyprogesterone): what it does and how to use it

Have you been handed a Provera prescription and want straight answers? Provera is the oral form of medroxyprogesterone acetate. Doctors prescribe it for things like irregular bleeding, absent periods (secondary amenorrhea), protecting the uterus when taking estrogen, and some off‑label uses such as managing endometriosis symptoms. It’s different from Depo‑Provera, which is the long‑acting injectable version used mainly for contraception.

Common side effects and red flags

Expect some short‑term effects: spotting, heavier or lighter bleeding, breast tenderness, headaches, tiredness, mood swings, or mild weight gain. Most people see these reduce after a few cycles. Some effects need urgent attention — sudden chest pain or breathlessness, severe leg swelling, very bad headaches or vision changes, yellowing of skin/eyes, or signs of an allergic reaction. If you get any of those, call your doctor or go to A&E right away.

Longer-term use of Depo‑Provera can lower bone density, so doctors usually avoid very long courses in younger people unless benefits outweigh risks. If you take Provera often, ask your provider about bone health and calcium/vitamin D.

How to take it, interactions, and what to expect

Follow your prescriber — doses vary by reason. A common short course to trigger a period is 10 mg daily for 5–10 days, but don’t copy that without checking first. Depo shots are given every 12 weeks. Provera can interact with enzyme‑inducing drugs like rifampicin, carbamazepine, phenytoin, and herbal products such as St. John's wort — these can make it less effective. If you’re on multiple meds, run them by your prescriber or pharmacist.

If you miss doses of oral Provera, check the leaflet or ask your prescriber. Missing pills can change bleeding patterns and reduce whatever protection the drug is providing in your particular treatment plan.

Safe buying and practical alternatives

In many countries Provera is prescription only. Be cautious with online pharmacies that sell it without asking for one. Look for clear contact details, verified pharmacy accreditation, and real pharmacist support. Very low prices, no prescription checks, or sloppy website info are red flags — avoid those.

Alternatives depend on why you were prescribed Provera. For menstrual control or endometrial protection, other progestins such as norethindrone or dydrogesterone may be used. A levonorgestrel IUD is a great option for long‑term local progestin effect and lighter periods. For contraception, Depo‑Provera, implants, or intrauterine devices may be better fits. Talk through pros and cons with your clinician — effectiveness, side effects, and future fertility plans all matter.

If you want more detail, check our guides on buying medication online safely and on drug alternatives. And if something feels off while you’re taking Provera, don’t wait — call your doctor and get it checked out.