Alprazolam alternatives: safer options for anxiety and panic

Alprazolam (Xanax) works fast, but it brings a high risk of dependence and tricky withdrawal. If you’re wondering what else can help, this page lays out clear, practical choices — both medicines and non-drug options — and what to expect when you switch.

Fast relief vs long-term options

For immediate relief of panic or severe anxiety, doctors sometimes use short-term options like hydroxyzine (an antihistamine with calming effects) or beta-blockers for the racing-heart, sweaty-palms type of anxiety (useful for performance anxiety). These act quickly but aren’t a long-term fix.

For ongoing control, SSRI and SNRI antidepressants (classes that include common options such as sertraline or escitalopram) are the main alternatives. They take a few weeks to start helping but reduce panic and generalized anxiety over months and have lower dependence risk than benzodiazepines. Buspirone is another non-addictive option for generalized anxiety, though it can also take weeks to work.

Other meds sometimes used off-label include pregabalin or gabapentin for certain anxiety types; they can help but have different side effects and may not be right for everyone. Your clinician can explain why one of these might or might not fit your situation.

Therapy, habits, and practical switching tips

Cognitive behavioral therapy (CBT) is highly effective for panic disorder and social anxiety. If you combine CBT with an SSRI or another non-benzodiazepine drug, results are often better than medication alone. Simple routines matter too: regular sleep, cutting back caffeine and alcohol, short daily walks, and breathing practice all lower baseline anxiety.

If you’re on alprazolam now, don’t stop suddenly. Withdrawal can be dangerous. Ask your prescriber for a gradual taper plan and a timeline for introducing an alternative. Expect the new medication to take time; your doctor may use a temporary short-acting option for panic during the switch.

When choosing an alternative, think about how fast you need relief, whether you’ve had past treatments, side effects you can’t tolerate, and the risk of dependence. Write down symptoms, triggers, and past meds before your appointment — that makes the conversation productive and gets you a tailored plan faster.

Finally, ask about follow-up. Switching meds and starting therapy need check-ins. If anxiety gets worse or you notice withdrawal signs, contact your prescriber right away. With the right mix of treatment and support, many people move off alprazolam while improving their day-to-day life.

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